Histological Effect of Acute Vitamin C Administration on the Testes of Adult Male Wistar Rats

Student: RITA OSEMUDIAMEN EBHODAGHE (Project, 2025)
Department of Anatomy
Ambrose Alli University, Ekpoma, Edo State


Abstract

This study investigated the histological effects of acute Vitamin C administration on the testes of adult male Wistar rats. Twelve rats were divided into three groups: a control group, a low-dose group (100 mg/kg), and a high-dose group (200 mg/kg), treated for 14 days. The results showed a slight increase in body weight in rats given Vitamin C, but no significant difference in testes weight between groups. Histological examination revealed normal testicular structure with healthy seminiferous tubules, Sertoli cells, and Leydig cells. The study concludes that Vitamin C has no harmful effects on the testes and may support male reproductive health, especially under oxidative stress conditions.

Keywords
Vitamin C Ascorbic acid Testicular histology Wistar rats Testes Antioxidant Reproductive health Histopathology Male fertility Experimental study Acute administration