The Effects of Coadministration of Methamphetamine and Vitamin C on the Liver of Adolescent Male Wistar Rat

Student: Somtochukwu Regina Nsofor (Project, 2025)
Department of Human Anatomy
Nnamdi Azikiwe University, Awka, Anambra State

Abstract

Methamphetamine is known to be toxic to humans, but its specific impact on vital organs such as the liver remains unclear. This study examined both the extent of methamphetamine-induced liver toxicity and the potential protective effects of vitamin C. Thirty-five adolescent male Wistar rats were divided into seven groups of five. Group A served as the control with normal feed and water. Groups B and C received 5 mg/kg and 10 mg/kg body weight of methamphetamine, respectively. Groups D and E received 300 mg/kg and 600 mg/kg body weight of vitamin C. Groups F and G received combinations of methamphetamine (5 mg/kg and 10 mg/kg) and vitamin C (300 mg/kg and 600 mg/kg). All treatments were administered orally for fourteen days. Twenty-four hours after the last dose, the rats were anesthetized, and liver tissues were collected for histological studies. Blood samples were obtained for biochemical analysis of liver enzymes. The serum levels of AST, ALT, and ALP in Groups B, C, and G were significantly higher (P

Keywords
effects coadministration methamphetamine vitamin liver adolescent wistar
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