Anti-Inflammatory, Antipyretic and Analgesic Properties of the Root Aqueous Extract of Mondia Whitei

ABSTRACT Mondia whitei, a tropical African herb with a long history of traditional medicinal use, has garnered interest for its potential therapeutic properties. This study explores its effectiveness in treating various ailments, particularly its anti-inflammatory, analgesic, and antipyretic effects. Introduction: The study explores the medicinal properties of Mondia whitei, a tropical African climbing herb known for its traditional use in treating various ailments. The herb is noted for potential anti-inflammatory, analgesic, and antipyretic effects, and this study aims to verify these properties in preclinical animal models. Aim: The study aims to evaluate the anti-inflammatory, analgesic, and antipyretic effects of concentrated root extracts of Mondia whitei using Swiss mice and Wistar rats. Method: The study involved administering different doses (25 mg/kg, 50 mg/kg, 100 mg/kg) of concentrated root extracts to adult Swiss mice and Wistar rats. Effects were assessed by measuring edema reduction (for anti-inflammatory), pain reduction (for analgesic), and fever reduction (for antipyretic) using various animal models. Statistical significance was tested at a p-value < 0.05. Results: Anti-inflammatory effects: Significant edema reduction was observed at 50 mg/kg and 100 mg/kg doses in Wistar rats. Analgesic effects: Both 50 mg/kg and 100 mg/kg doses significantly reduced pain in acetic acid and formalin-induced pain models. Antipyretic effects: The 50 mg/kg dose significantly reduced fever induced by baker's yeast after four hours. All effects were statistically significant (p < 0.05). Conclusion: Mondia whitei exhibits significant anti-inflammatory, analgesic, and antipyretic effects, with further research needed to identify bioactive compounds and explore its modern medical potential.