Profiling of Wistar Rats After Subacute Administration of Annona Muricata Fruit and Leaf Aqueous Extract on Kidney Function Indices in Wistar Rats

This study investigated the impact of a 14-day oral administration of Annona muricata (soursop)
leaves and fruits on kidney function in male Wistar rats. The experiment involved forty (40)
mature male rats of average weight 174.86 ±3. 20g were randomized into 10 groups (A-J), each
containing four rats, to evaluate the nephroprotective or nephrotoxicity effects of the plant
extracts. Groups A served as control groups, received distilled water only. Groups B, C and D
received 100,200, and 400mg/kg of aqueous extract of Annona muricata fruits respectively,
while Groups E, F and G received 200mg/kg of aqueous extract of Annona muricata leaves
respectively and Groups I, J and K received 200mg/kg of aqueous extract of Annona muricata
fruits and leaves at 1:1,1:2 and 2:1 respectively. 1ml of the extract doses were administered daily
for consecutive 14 days. Parameters of kidney function (urea, uric acid, electrolytes; Na+
, Cl- K
+
,
Bicarbonate ion, creatinine) were evaluated using standard procedures. The exposure of male
Wister rat to aqueous extract of Annona muricata showed significant (p˂0.05) increase in all the
electrolytes, significant (p˂0.05) decrease in serum creatinine and uric acid and no significant
(p˃0.05) alteration in urea The results indicated mild toxicity of oral administration of aqueous
extract of Annona muricata. therefore caution must be taken in the oral consumption of Annona
muricata leaf and fruit extract