In Silico Studies of Bioactive Compounds from Curcuma Longa as Amp Beta-Lactamase Inhibitors

Student: Hamzah Adinoyi Abdulkabir (Project, 2025)
Department of Biochemistry
Lagos State University, Ojo, Lagos State

Abstract

ABSTRACT
Traditionally natural herbal treatments were used to treat ailments in both humans and-animals. However, the introduction of synthetic medications resulted in a loss of interest in, if not outright disregard for, herbal therapies_ Lifestyle, food, medication resistance among microorganisms, and the limitations of synthetic pharmaceuticals have pushed scientists to review and evaluate these abandoned natural remedies. Resistance of microbes to antibiotics has emerged as a significant global health concern, claiming millions of lives. With microbes develepoing resistance to the current synthetic drugs used against them, there's a pressing need for developing new anti biotics. The study shows that phytochenicals from medicinal plants can bind to and inhibit E.coli's AmpC beta-lactamases, with compounds like beta carotene, campesterol, beta sitosterol, and 2 hydroxylmethyl anthraquinone showing promising antimicrobial properties. However, molecular docking is used, and further validation through in vitro and in vivo experiments is recommended to determine their efficacy.

Keywords
medicinal plants phytochemicals E. coli AmpC beta-lactamase antibiotic resistance beta carotene campesterol beta sitosterol antimicrobial agents molecular docking natural remedies in vitro validation in vivo studies
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