Antimalarial and Antibacterial Activities of Extract from Fungal Endophyte

Student: Oluwatise Olajumoke Owolabi (Project, 2025)
Department of Microbiology
Ekiti State University, Ado-Ekiti, Ekiti State

Abstract

Fungal endophytes have gained significant attention as potential sources of bioactive
compounds with antimicrobial properties. This study investigates the antimalarial and
antibacterial activities of extracts derived from fungal endophytes, focusing on their
biofilm inhibition, eradication, and bactericidal efficacy. The 4AP extract from
Aspergillus nidulans exhibited notable antimicrobial activity, demonstrating strong
biofilm inhibition, biofilm eradication, and bacterial elimination in time-kill assays. In
contrast, the 6P extract showed moderate effects, while CP2 from Aspergillus flavus
exhibited negative inhibition, indicating potential biofilm-promoting properties. The
findings align with previous studies on fungal secondary metabolites, emphasizing their
role in disrupting bacterial quorum sensing and biofilm formation. Additionally, lipid
peroxidation and protein determination assays provided insights into the oxidative and
metabolic profiles of plant isolates, with Carica papaya demonstrating strong antioxidant
potential and high protein content. The study underscores the potential of fungal-derived
extracts for antimicrobial applications while highlighting the necessity for further
chemical characterization to ensure their efficacy and safety.

Keywords
antimalarial antibacterial activitiees extract fumgal endophyte
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