Effects of Chronic Sleep Deprivation on the Histological Architecture of the Kidney in Rats With Peptic Ulcer Disease.

ABSTRACT BACKGROUND: Chronic sleep deprivation and peptic ulcer disease are prevalent health issues, each contributing independently to oxidative stress, inflammation, and hormonal imbalances. The kidneys, vital for homeostasis, are particularly susceptible to systemic stressors. However, the combined effects of sleep deprivation and peptic ulcer disease on renal histology remain poorly understood. This study investigates the histological impacts of these conditions on the kidneys, focusing on potential synergistic effects and recovery outcomes. AIM: To evaluate histological alterations in the renal tissues of Wistar rats exposed to chronic sleep deprivation and experimentally induced peptic ulcer disease. METHODS: Thirty Wistar rats were grouped into six experimental categories: control, peptic ulcer-induced, sleep-deprived (7 days), combined sleep deprivation and peptic ulcer-induced, and recovery groups with one day of rest post-exposure. Peptic ulcer disease was induced using the acetic acid method, while sleep deprivation was implemented via gentle handling. Renal tissues were harvested and analyzed histologically. RESULTS: Histological analysis revealed significant findings. Control rats displayed normal renal architecture. The peptic ulcer group exhibited mild tubular and glomerular changes, while the sleep-deprived group showed moderate interstitial inflammation and tubular dilatation. Combined exposure to sleep deprivation and peptic ulcer disease resulted in severe renal damage, including glomerular disruption and tubular necrosis, indicating synergistic effects. Recovery groups showed partial histological improvements, with residual abnormalities persisting, suggesting limited renal repair over short recovery intervals. CONCLUSION: This study underscores the interplay between gastrointestinal disturbances, sleep deprivation, and renal health. Both conditions converge on shared pathological pathways, exacerbating renal injury. Findings highlight the necessity for integrated management strategies addressing sleep hygiene, gastrointestinal health, and renal monitoring to mitigate systemic complications. Future research should explore extended recovery periods and therapeutic interventions to promote renal repair and resilience.