Assessment of Toxic Effects of Cyclophosphamide Administration on the Heart and Lungs of Wistar Rats
Student: Boluwatife Olamide Oladipupo (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
ABSTRACT Cyclophosphamide (CP), a potent chemotherapeutic and immunosuppressive agent, is widely used to treat various cancers and autoimmune diseases. Despite its therapeutic efficacy, CP administration is associated with significant toxic side effects, particularly cardiotoxicity and pulmonary toxicity. This study aims to assess the toxic effects of cyclophosphamide on the heart and lungs of adult Wistar rats. The study involves histological examination and evaluation of toxicity levels in the heart and lungs after administering different doses of cyclophosphamide. The results will provide insight into the extent of damage caused by cyclophosphamide, potentially guiding further research and regulatory considerations. Through a detailed analysis of tissue samples and statistical comparison across different dosage groups, this research seeks to enhance our understanding of CP-induced toxicity and contribute to the development of strategies to mitigate its adverse effects.
Keywords
For the full publication, please contact the author directly at: oladipupoboluwatife9@gmail.com
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Institutions
- Covenant Polytechnic, Aba, Abia State 1
- Covenant University, Canaan Land, Ota, Ogun State 4
- Crawford University of Apostolic Faith Mission Faith City, Igbesa, Ogun State 2
- Crescent University, Abeokuta, Ogun State 1
- Cross Rivers University of Technology, Calabar, Cross Rivers State 142
- Delta State Polytechnic, Ogwashi-Uku, Delta State 11
- Delta State Polytechnic, Otefe, Delta State 12
- Delta State University, Abraka, Delta State 139
- Ebonyi State University, Abakaliki, Ebonyi State 17
- Edo University, Iyamho, Edo State 10