Neurobehavioral and Biochemical Effect of Cinnamonum Verum Bark Extract Following Streptozotocin (stz) Induced Neurotoxicity on Male Wistar Rats

Neurodegenerative diseases pose a significant health challenge, often linked to
oxidative stress and inflammation. Streptozotocin (STZ) is a well-known neurotoxin
used to induce experimental neurotoxicity in animal models. This study investigates
the potential neuroprotective effects of Cinnamomum verum bark extract on STZ-
induced neurotoxicity in male Wistar rats. Twenty five(25)Male Wistar rats
weighing between 80-100kg were divided into five groups: A control group, GroupB
65mg/kg STZ-induced, Group C 65mg/kg STZ + 200mg/kg cinnamomum verum
extract, Group D 65mg/kg STZ-induced + 400mg/kg Cinnamonum Verum extract
and Group E 600mg/kg Cinnamomum verum extract for 28 days. STZ was
administered intraperitoneally to induce neurotoxicity, followed by oral
administration of Cinnamomum verum bark extract. Neurobehavioral test using y-
maze were conducted to assess cognitive functions, including memory and learning
abilities. Biochemical assays measured oxidative stress markers, and
neurotransmitter levels in the brain tissue.Hippocampal absorbance rates and latency
periods were also measured to assess hippocampal intergrity and cognitive
performance. Rats treated with Cinnamomum verum bark extract showed a
significant increase in cognitive functions compared to the STZ-induced group.
There was a marked reduction in oxidative stress markers, such as malondialdehyde
(MDA), and an increase in antioxidant enzymes like superoxide dismutase (SOD)
and Glutathione.Treatment with Cinnamomum verum bark extract particularly in
Group D and E,significantly reduced (p≤0.005) MDA levels and restored SOD and
GTT levels,suggesting enhanced antioxidant protection. In the Y-maze,the STZ only
group showed prolonged latency periods, reflecting impaired spatial learning and
memory. Cinnamonum verum bark treatment notably reduced latency period in
Group D and E,demonstrating improved cognitive function.Furthermore,
hippocampal absorbance rates were significantly attenuates STZ induced cognitive
impairment in male wistar rats.The extract enhances antioxidant defenses,reduces
oxidative stress and improves cognitive performance,suggesting its potential as a
therapeutic agent for Alzheimer’s disease.