Effect of Ficus Glumosa Leaf on Alkaline Phosphatase Alp and Aspartate Amino Transferase Ast on Plasmodium Berghei-Infected Mice

ABSTRACT
challenge worldwide. Ficus glumosa, a plant known for its medicinal
and group 6 served as the normal control (non-parasitized, normal diet). The
Malaria, caused by Plasmodium parasites, remains a significant public health
Artesunate; group 5 served as the negative control (parasitized but untreated);
acclimatized and then 30 0f these mice were inoculated intraperitoneally with
infection in mice, as evidenced by the significant reduction in serum ALP and
effect against hepatic and muscular damage induced by Plasmodium berghei
chloroquine-sensitive Plasmodium berghei(NK-65) obtained from the
Plasmodiumberghei. Fresh leaves of Ficus glumosawere harvested from the
AST levels. Further research is warranted to elucidate the underlying
into six groups: groups 1, 2, and 3 received diets incorporated with 5g, 10g, and
0.2ml blood suspension containing 1 X 106parasitized erythrocytes of
results of this study suggest that Ficusglumosaleaf extract has a protective
Nigerian Institute of Medical Research (NIMR), Lagos. The mice were divided
management of malaria.
properties, has been used traditionally to treat various ailments. This study was
(ALP) and aspartate aminotransferase (AST) levels in mice infected with
normal rat chow. A total of 36 mice, weighing between 23g to 35g, were
mechanisms and potential therapeutic applications of Ficus glumosain the
University of Cross River State (UNICROSS), Calabar, Nigeria. The leaves
aimed to investigate the effect of Ficus glumosaleaf on alkaline phosphatase
were blended and incorporated into diets at 5%, 10%, and 20% per 100g of
20g of Ficus glumosaleaves respectively; group 4 received 5mg/kg BW of
Keywords:Ficus glumosa,Plasmodium berghei, alkaline phosphatase,
aspartate aminotransferase, malaria, mice, medicinal plants.