Assessing the Impact of Saccharomyces Cerevisiae Strain M6865964 on Some Reproductive Parameters, Serologic Analysis and Uterine Histology in Rabbit Does

ABSTRACT
Saccharomyces cerevisiae [SCH] commonly known as baker’s yeast, has been widely studied for its probiotic and nutritional benefits in animal nutrition. Its potential effects on reproductive parameters, serum biochemistry, and uterine histology in rabbits remain an area of interest due to its influence on gut health, immune function, and metabolic processes. This study investigated the impact of Saccharomyces cerevisiae supplementation on reproductive performance, biochemical indices, and uterine morphology in female rabbits. A total of 16 female rabbits were divided into 4 groups [A-D] of 4 female rabbits each – with A,B,C receiving Saccharomyces cerevisiae-supplemented diets at 0.10 in 1kg of feed ,0.15 in 1kg of feed , and 0.20 respectively from a period of introduction to male till end of gestation period while D served as control and were fed without the supplement . Reproductive parameters such as gestation length, body weight of does before and after kindling were evaluated. Blood samples and uterus samples were collected 14 days post gestation . Blood samples were analyzed for biochemical markers, including glucose, cholesterol and liver enzymes . Uterine histology was assessed to identify potential structural modifications. The result of this study showed that treatment with SCH significantly altered the level of stress markers in those fed with higher doses of SCH . Serum glucose, cholesterol, magnesium, creatinine decreased with increasing dose of SCH . Increase in calcium level with increasing doses of SCH was observed. Treatment with graded doses of SCH did not alter gestational length for the groups. Change in body weight of does during before and after kindling was observed. The result of this study showed that SCH at the dose of 0.20kg produced desired effects beneficial for reproductive abilities.The findings of this study will contribute to understanding the role of yeast probiotics in enhancing reproductive efficiency and overall health in rabbits. Results from this study may have implications for rabbit farming and small-scale livestock production, providing a natural alternative for improving reproductive performance.