Effect of Topical Application of Lactobacillus Fermentum and Its Cell-Free Extract on Infected Wound Healing in Wistar Rats
Student: Tobiloba Oyekunle Oyediran (Project, 2025)
Department of Microbiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Wound infections delay healing and pose major challenges in treatment. This research evaluates the healing effect of Lactobacillus fermentum and its cell-free extract (CFE) on infected wounds in Wistar rats. The probiotic strains demonstrated tolerance to different pH, temperature, and salt levels. Histological results revealed that natural healing showed better tissue recovery compared to the probiotic-treated group, which displayed prolonged inflammation and delayed epithelialization. However, the probiotic-treated wounds showed enhanced collagen I and III deposition and lower fibrinogen levels, indicating potential anti-inflammatory effects. These findings suggest that while L. fermentum influences wound healing mechanisms, further studies are needed to optimize its topical efficacy.
Keywords
For the full publication, please contact the author directly at: oyedirantobiloba8@gmail.com
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Institutions
- Sokoto State University, Sokoto, Sokoto State 42
- St. Albert The Great Major Seminary, Abeokuta. (affl. To University of Benin) 1
- Sule Lamido University, Kafin Hausa, Jigawa State 4
- Tai Solarin University of Education, Ijagun, Ogun State 18
- Tansian University, Oba, Anambra State 1
- Taraba State University, Jalingo, Taraba State 32
- Temple-Gate Polytechnic, Osisioma, Abia State 1
- The Oke-Ogun Polytechnic, Saki, Oyo State 6
- The Polytechnic, Ibadan, Oyo State 13
- THOMAS ADEWUMI UNIVERSITY, OKO-IRESE, KWARA STATE 1