Effect of Topical Application of Lactobacillus Fermentum and Its Cell-Free Extract on Infected Wound Healing in Wistar Rats
Student: Tobiloba Oyekunle Oyediran (Project, 2025)
Department of Microbiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Wound infections delay healing and pose major challenges in treatment. This research evaluates the healing effect of Lactobacillus fermentum and its cell-free extract (CFE) on infected wounds in Wistar rats. The probiotic strains demonstrated tolerance to different pH, temperature, and salt levels. Histological results revealed that natural healing showed better tissue recovery compared to the probiotic-treated group, which displayed prolonged inflammation and delayed epithelialization. However, the probiotic-treated wounds showed enhanced collagen I and III deposition and lower fibrinogen levels, indicating potential anti-inflammatory effects. These findings suggest that while L. fermentum influences wound healing mechanisms, further studies are needed to optimize its topical efficacy.
Keywords
For the full publication, please contact the author directly at: oyedirantobiloba8@gmail.com
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Institutions
- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 119
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 363
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14