The Effect of Chronic Sleep Deprivation on the Antioxidant Markers of Hearts of Rats Induced With Peptic Ulcer

Student: Jeffery Iretomiwa Ogungbuaro (Project, 2025)
Department of Human Physiology
Ekiti State University, Ado-Ekiti, Ekiti State

Abstract

The Impact of Sleep Deprivation on Peptic Ulcer Development and Progression Sleep deprivation, a prevalent modern-day issue, has been linked to various health complications. This study investigates the relationship between sleep deprivation and the development and progression of peptic ulcers. Peptic ulcers are painful sores in the lining of the stomach or duodenum, often caused by a combination of factors, including Helicobacter pylori infection and excessive acid production. Research suggests that chronic sleep deprivation can disrupt the body’s stress response, leading to increased cortisol levels. Elevated cortisol levels can promote gastric acid secretion and impair mucosal barrier integrity, making individuals more susceptible to peptic ulcer development. Additionally, sleep deprivation may negatively impact the immune system, hindering the body’s ability to combat H. pylori infection. This study aims to explore the mechanisms underlying the association between sleep deprivation and peptic ulcer disease, providing valuable insights for prevention and treatment strategies

Keywords
effect chronic sleep deprivation antioxidant markers hearts induced peptic ulcer
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