Effects of Ginger-Based Diets and Turmeric-Based Diets on Gluthathione-S-Transrerase Activity in the Brain and Serum of D-Galactose Induced Aging Rats.

Student: Ajoke Kareemat Olasupo (Project, 2025)
Department of Biochemistry
Ekiti State University, Ado-Ekiti, Ekiti State

Abstract

The effect of Ginger (Zingiber officinale R) based-diets and Turmeric (Curcuma longa L)based-dietson glutathione-s-transferase activities in serum and brain of D-galactose induced aging rats. Group 1(control group),Group 2(D-galactose induced),Group 3(D-galactose induced+2% turmeric powder),Group 4(D-galactose induced + 4% turmeric powder), Group 5(D-galactose induced + 2% ginger powder), Group 6(D-galactose induced + 4% ginger powder), Group 7(D-galactose induced +vitamin E(150mg/kg)). At the end of the feeding experiment,the animals were euthanized in chloroform anaesthesia and sacrificed. Blood was collected via cardiac puncture and the brain samples were harvested. Group 1 was which is the control group, Group 2(untreated) GSH activities on the brain and serum was significantly decreased compared to the other group. Group 5(Ginger at 2%) shows that there was little effect if GSH activities on the brain and serum of D-galactose induced aging rats. This study suggests that ginger can improve antioxidant status in oxidative stress.

Keywords
glutathione-s-transferase D-galactose Zingiber officinale Curcuma longa chloroform serum antioxidant oxidative aging rats.
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