Assessment of Sterility of Five Different Brands of Injectable Gentamicin

Student: AISHA HARUNA MUHAMMAD (Project, 2025)
Department of Pharmaceutical Technology
Kano State Polytechnic, Kano, Kano State

Abstract

Sterility testing is a critical component of pharmaceutical quality control, especially for injectable drugs like gentamicin that bypass natural immune barriers upon administration. Ensuring these antibiotics are free from microbial contamination is essential to avoid severe health risks in patients. Traditional sterility testing methods include membrane filtration and direct inoculation; however, each method has its limitations, particularly when dealing with antibiotics possessing inherent antimicrobial properties (Sutton, 2011). This study investigates the direct inoculation method's effectiveness in detecting microbial contaminants in injectable gentamicin.
Substandard and falsified medicines are an enormous threat to global health. Poor quality antibiotic preparations contribute to the development of antimicrobial resistance. In surgery, where the occurrence of healthcare-associated infections is high, healthcare teams need to rely on the quality of antibiotic prophylaxis to prevent infections. We assessed the quality of antibiotics used for surgical infection prophylaxis in Benin

Keywords
quality sterility injectable gentamicin antibiotics testing microbial health direct inoculation
Filters
Institutions