Anitioxidative Effect of Gongronema Latifolium Ethanol Leave Extract on Testosterone Propionate-Induced Benign Prostate Hyperplasia in Wister Rats

Student: Innocent Akobi Obembem (Project, 2025)
Department of Medical Biochemistry
Cross Rivers University of Technology, Calabar, Cross Rivers State

Abstract

The aim of this study is to evaluate the anti-oxidative effect of Gongronema latifolium ethanol leave extract on testosterone propionate induced-benign prostate hyperplasia in male Wister rats. A total of twenty eight (28) mature male wister rats weighing between200-300g were grouped into four (4) with seven (7) rats each. Group I serve as normal control and received 0.4ml of distilled water. GroupII served as the BPH control group. Group II to IV animals received subcutaneous injection of 3mg/kg testosterone for twoweeks, after which group III were treated with gongronema latifolium (150mg/kg body weight). Group IV: BPH rats were treated with5mg/70kg finasteride (standard drug for treatment of Benign ProstateHyperplasia) for four weeks. All animals were euthanized on the 29th day, following an overnight fast and blood samples obtained for biochemical analysis. The results obtained showed that induction of BPH (p

Keywords
Benign prostatic hyperplasia (BPH) Pathophysiology Testosterone Propionate (TP) Gongronema Latifolium Phytochemical Pharmacological
Filters
Institutions