Effects of Ethanol Extract of Alligator Pepper (aframomum Melegueta) as Well as Serotonin Precursor on Learning and Memory in Cd 1 Mice
Student: Divine-Favour Otemdiri Osam (Project, 2025)
Department of Science Laboratory Technology
University of Calabar, Calabar, Cross River State
Abstract
Alzheimer’s disease (memory impairment) disorder is on the increase worldwide. Whetheradministration of ethanol extract of alligator pepper and serotonin precursor (5-Hydroxytryptophan)diets can ameliorate memory impairment has not been previously ascertained. Therefore, this research was to study the effects of administration of alligator pepper as well as serotoninprecursor diets in mice. Forty mice were randomlyassigned into 4groups (10 mice per group) namely; Control, alligator pepper only,5-HT plus alligator pepper, and 5-HT only. Preliminary studies onphytochemical analysis were done before learning/memory was also studied. Standardmethods were used to study learning/memory. The results showed that preliminaryphytochemical screening of 5-HT indicated the presence of flavonoids, alkaloids, andpolyphenols(antioxidants). Learning was impaired in the Control only group compared toother test groups (p
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- Landmark University, Omu-Aran, Kwara State 1
- Lead City University, Ibadan, Oyo State 1
- Lens Polytechnic, offa, Kwara State. 215
- Madonna University, Elele, Rivers State 20
- Madonna University, Okija, Anambra State 2
- Mcpherson University, Seriki Sotayo, Ogun State 1
- Michael and Cecilia Ibru University, Owhrode, Delta State 1
- Michael Okpara University of Agriculture, Umudike 43
- Michael Otedola Col of Primary Educ. Epe, Lagos (affl To University of Ibadan) 8
- Modibbo Adama University, Yola, Adamawa State 15