Antimalarial Activity of Andrographis Paniculata and Impact on Homeostasis Model Assessment of Insulin Resistance (homa-Ir)
Student: IFEANYI EMMANUEL CHIAZOR (Project, 2025)
Department of Medical Biochemistry
Delta State University, Abraka, Delta State
Abstract
Malaria remains a critical public health challenge, exacerbated by the emergence of drug-resistant strains of Plasmodium. Concurrently, malaria infection has been implicated in disrupting glucose metabolism, contributing to insulin resistance. This study investigates the antimalarial activity of Andrographis paniculata and its impact on insulin resistance, as measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), using Plasmodium berghei as a model parasite in mice. Results indicated a substantial reduction in parasitamia levels and increased survival rates in treated mice compared with controls. This study highlights Andrographis paniculata as a promising candidate for novel antimalarial therapies, offering benefits that extend beyond parasitic clearance to ameliorating insulin resistance. This observation warrants further investigation
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Institutions
- Redeemers University, Ede, Osun State 4
- Rhema University, Aba, Abia State 11
- Rivers State University of Science and Technology, Port Harcourt, Rivers State 3
- RIVERS STATE UNIVERSITY, PORT HARCOURT, RIVERS STATE 13
- Rufus Giwa Polytechnic, Owo, Ondo State 2
- Saadatu Rimi College of Edu, Kumbotso, Kano State (affiliated To Abu, Zaria) 1
- Salem University, Lokoja, Kogi State 4
- School of Health Information Mgt (Uch, Ibadan), Oyo State 5
- School of Health Information Mgt, Oau Teaching Hospital, Ile-Ife, Osun State 30
- Skyline University Nigeria, Kano, Kano State 2