Antimalarial Activity of Andrographis Paniculata and Impact on Homeostasis Model Assessment of Insulin Resistance (homa-Ir)
Student: IFEANYI EMMANUEL CHIAZOR (Project, 2025)
Department of Medical Biochemistry
Delta State University, Abraka, Delta State
Abstract
Malaria remains a critical public health challenge, exacerbated by the emergence of drug-resistant strains of Plasmodium. Concurrently, malaria infection has been implicated in disrupting glucose metabolism, contributing to insulin resistance. This study investigates the antimalarial activity of Andrographis paniculata and its impact on insulin resistance, as measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), using Plasmodium berghei as a model parasite in mice. Results indicated a substantial reduction in parasitamia levels and increased survival rates in treated mice compared with controls. This study highlights Andrographis paniculata as a promising candidate for novel antimalarial therapies, offering benefits that extend beyond parasitic clearance to ameliorating insulin resistance. This observation warrants further investigation
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For the full publication, please contact the author directly at: abegnegobrown@gmail.com
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- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 116
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14