Evaluation of Oxidative Stress and Histoarchitecture of the Pituitary Gland in Male Wistar Rats Exposed to Tramadol and Vitamin D3 Supplementation.
Student: Somtochukwu Juliet Okeke (Thesis, 2025)
Department of Anatomy
Nnamdi Azikiwe University, Awka, Anambra State
Abstract
Tramadol is an opioid drug used for pain relief. Vitamin D3 also called cholecalciferol is a fat-soluble vitamin that helps in absorption of calcium. This study investigated the effects of vitamin D3 on oxidative status and histoarchitecture of pituitary gland in male Wistar rats following exposure to tramadol. Fifteen (15) male Wistar rats weighing about 110g were divided into 3 groups of 5 rats each. Group A received only feed and distilled water. Group B received 20 mg/kg of Tramadol and Group C received 20 mg/kg of tramadol and 25 mcg/kg of Vitamin D3. Administration was through an oral route and lasted for 28 days. Animals were euthanized 24 hours after the last administration by cervical dislocation. Pituitary gland was collected for analysis and the results were analyzed by SPSS version 25. Results showed significant increase in the animal body weight in all groups (p
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For the full publication, please contact the author directly at: okekesomtochukwujuliet@gmail.com
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- Al-Hikmah University, Ilorin, Kwara State 2
- AL-ISTIQAMAH UNIVERSITY, SUMAILA, KANO STATE 1
- Al-Qalam University, Katsina, Katsina State 5
- Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State 87
- Alvan Ikoku College of Education, Imo State, (Affl To Univ of Nigera, Nsukka) 11
- Ambrose Alli University, Ekpoma, Edo State 478
- Anambra State College of Health Technology, Obosi, Anambra State 1
- Auchi Polytechnic, Auchi, Edo State 503
- Auchi Polytechnic, Auchi, Edo State. (affl To Nnamdi Azikiwe University, Awka) 3
- Audu Bako College of Agriculture Danbatta, Kano, Kano State 54