Effect of Nigella Sativa on Permerthrin-Induced Hepatotoxicity in Adult Male Wistar Rats
Student: Shuaibat Yetunde Yusuf (Project, 2025)
Department of Anatomy
University of Ilorin, Kwara State
Abstract
This study has focused on the hepatotoxic effects of permethrin on the liver of adult male Wistar rats. Forty adult male Wister rats were divided into four groups, of which Group A was exposed to 0.5 mL of normal saline per kg of rat, while Group B was exposed to permethrin orally at a dosage of 1000 mg/kg of feed for four weeks. Group C was administered Nigella sativa oil at dose of 5 mL/kg of rat and Group D was exposed to both permethrin and Nigella sativa oil, given at the same dose as Group B and Group C. The liver was excised for histological and histochemical analysis. Oxidative status and lipid peroxidation were analyzed by determining biomarkers such glutathione peroxidase, superoxide dismutase, and malondialdehyde. The functions of liver enzymes, alanine transferase, aspartate aminotransferase, alkaline phosphatase were also asusessed. These findings have shown that permethrin caused a reduction in body weight and also an increase in liver weight. Keywords: permethrin, hepatotoxicity, liver morphology, oxidative stress
Keywords
For the full publication, please contact the author directly at: shuaibat29@gmail.com
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Institutions
- Sokoto State University, Sokoto, Sokoto State 42
- St. Albert The Great Major Seminary, Abeokuta. (affl. To University of Benin) 1
- Sule Lamido University, Kafin Hausa, Jigawa State 4
- Tai Solarin University of Education, Ijagun, Ogun State 18
- Tansian University, Oba, Anambra State 1
- Taraba State University, Jalingo, Taraba State 32
- Temple-Gate Polytechnic, Osisioma, Abia State 1
- The Oke-Ogun Polytechnic, Saki, Oyo State 6
- The Polytechnic, Ibadan, Oyo State 13
- THOMAS ADEWUMI UNIVERSITY, OKO-IRESE, KWARA STATE 1