Effect of Nigella Sativa on Permerthrin-Induced Hepatotoxicity in Adult Male Wistar Rats
Student: Shuaibat Yetunde Yusuf (Project, 2025)
Department of Anatomy
University of Ilorin, Kwara State
Abstract
This study has focused on the hepatotoxic effects of permethrin on the liver of adult male Wistar rats. Forty adult male Wister rats were divided into four groups, of which Group A was exposed to 0.5 mL of normal saline per kg of rat, while Group B was exposed to permethrin orally at a dosage of 1000 mg/kg of feed for four weeks. Group C was administered Nigella sativa oil at dose of 5 mL/kg of rat and Group D was exposed to both permethrin and Nigella sativa oil, given at the same dose as Group B and Group C. The liver was excised for histological and histochemical analysis. Oxidative status and lipid peroxidation were analyzed by determining biomarkers such glutathione peroxidase, superoxide dismutase, and malondialdehyde. The functions of liver enzymes, alanine transferase, aspartate aminotransferase, alkaline phosphatase were also asusessed. These findings have shown that permethrin caused a reduction in body weight and also an increase in liver weight. Keywords: permethrin, hepatotoxicity, liver morphology, oxidative stress
Keywords
For the full publication, please contact the author directly at: shuaibat29@gmail.com
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- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 116
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 239
- University of Ibadan, Ibadan, Oyo State 14