Evaluation of the Analgesic Activity of the Hydro-Methanolic Stem Extract of Costus Afer Ker Gawl (costaceae) in Mice.
Student: Fatima Iliyasu (Project, 2025)
Department of Pharmacy
Kaduna State University, Kaduna, Kaduna State
Abstract
ABSTRACT The present research was carried out to evaluate the analgesic activity of the hydro methanolic stem extract of Costus afer in mice. Intraperitoneal acute toxicity (LDs) test of the extract was carried out. The intraperitoneal LDs0 value was estimated to be greater than 5000 mg/kg in mice, indicating that the stem extract was relatively non toxic. The hydro methanolic stem extract of Costus afer at 250, 500, and 1000 mg/kg body weight produced significant (p < 0.05, p < 0.01) and dose dependent inhibitions of the acetic acid induced abdominal contractions and hot plate test in mice. The result indicates that the hydro methanolic stem extract of Costus afer has analgesic activity and justifies its traditional use in pain management.
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- Ekiti State University 58
- Ekiti State University, Ado-Ekiti, Ekiti State 881
- Elizade University, Ilara-Mokin, Ondo State 100
- Emmanuel Alayande College of Education, Oyo. (affl To Ekiti State Univ) 2
- Enugu State Polytechnic, Iwollo, Enugu State 4
- Enugu State University of Science and Technology, Enugu, Enugu State 29
- Evangel University, Akaeze, Ebonyi State 2
- FCT COLLEGE OF EDUCATION, ZUBA ,( AFFILIATED TO ABU, ZARIA), FCT-ABUJA 5
- Federal College of Agricultural Produce Tech, Hotoro Gra Ext, Kano, Kano State 2
- Federal College of Educ. (Special), Oyo, Oyo State (Aff To Uni. Ibadan) 10