Ameliorative Effect of Citrullus Lanatus Aqueous Seed Extract on Pah-Induced Organ Damage in Albino Rats
Student: Uche Oliveth Ugochukwu (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants known to induce oxidative stress and organ toxicity through bioactivation and generation of reactive oxygen species. This study investigated the ameliorative effect of Citrullus lanatus (watermelon) aqueous seed extract on PAH-induced organ damage in albino rats. Thirty adult male albino rats were randomly divided into five groups (n=6): control, PAH-treated, and three treatment groups receiving PAH with varying doses of C. lanatus seed extract (100, 200, and 400 mg/kg body weight) for 28 days. Biochemical markers of hepatic and renal function (AST, ALT, ALP, urea, creatinine) as well as oxidative stress indices (MDA, SOD, CAT, and GSH) were assessed, alongside histopathological evaluation of liver and kidney tissues.
Keywords
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Institutions
- HASSAN USMAN KATSINA POLYTECHNIC (NCE), KATSINA, KATSINA STATE 4
- Hassan Usman Katsina Polytechnic, Katsina, Katsina State 5
- Heritage Polytechnic, Ikot Udota, Akwa Ibom State 46
- Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State 8
- Ibrahim Badamasi Babangida University, Lapai, Niger State 24
- Igbinedion University, Okada, Benin City, Edo State 2
- Ignatius Ajuru University of Education, Port Harcourt, Rivers State 8
- Imo State Polytechnic, Umuagwo, Owerri, Imo State 3
- Imo State University, Owerri, Imo State 45
- Institute of Management and Technology, Enugu, Enugu State 11