Ameliorative Effect of Citrullus Lanatus Aqueous Seed Extract on Pah-Induced Organ Damage in Albino Rats
Student: Uche Oliveth Ugochukwu (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants known to induce oxidative stress and organ toxicity through bioactivation and generation of reactive oxygen species. This study investigated the ameliorative effect of Citrullus lanatus (watermelon) aqueous seed extract on PAH-induced organ damage in albino rats. Thirty adult male albino rats were randomly divided into five groups (n=6): control, PAH-treated, and three treatment groups receiving PAH with varying doses of C. lanatus seed extract (100, 200, and 400 mg/kg body weight) for 28 days. Biochemical markers of hepatic and renal function (AST, ALT, ALP, urea, creatinine) as well as oxidative stress indices (MDA, SOD, CAT, and GSH) were assessed, alongside histopathological evaluation of liver and kidney tissues.
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Institutions
- Mohammed Lawan College of Agriculture, Maiduguri, Borno State 12
- Moshood Abiola Polytechnic, Abeokuta, Ogun State 7
- Nasarawa State University, Keffi, Nasarawa State 8
- Niger Delta University, Wilberforce Island, Bayelsa State 28
- Niger State College of Education, Minna, (Affl To Usmanu Danfodiyo Uni, Sokoto) 1
- Nigeria Maritime University, Okerenkoko, Delta State 1
- Nigerian Army University, Biu, Borno State 3
- Nile University of Nigeria, Abuja 3
- Nnamdi Azikiwe University, Awka, Anambra State 98
- Northwest University, Kano, Kano State 179