Ameliorative Effect of Citrullus Lanatus Aqueous Seed Extract on Pah-Induced Organ Damage in Albino Rats
Student: Uche Oliveth Ugochukwu (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants known to induce oxidative stress and organ toxicity through bioactivation and generation of reactive oxygen species. This study investigated the ameliorative effect of Citrullus lanatus (watermelon) aqueous seed extract on PAH-induced organ damage in albino rats. Thirty adult male albino rats were randomly divided into five groups (n=6): control, PAH-treated, and three treatment groups receiving PAH with varying doses of C. lanatus seed extract (100, 200, and 400 mg/kg body weight) for 28 days. Biochemical markers of hepatic and renal function (AST, ALT, ALP, urea, creatinine) as well as oxidative stress indices (MDA, SOD, CAT, and GSH) were assessed, alongside histopathological evaluation of liver and kidney tissues.
Keywords
For the full publication, please contact the author directly at: chauntel955@gmail.com
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- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 116
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14