Antihyperlipidemia Activity of Methanol Extract of Jatropha Tanjorensis on Diabetic Male Drosophila Melanogaster
Student: Victoria AWO IJI (Project, 2025)
Department of Biochemistry
Usmanu Danfodio University, Sokoto, Sokoto State
Abstract
Diabetes and hyperlipidemia are prevalent metabolic disorders that contribute significantly to global health burdens. The search for effective, natural therapeutic agents has gained attention due to their potential in managing these conditions. This study investigates the antidiabetic and antihyperlipidemic effects of J. tanjorensis methanol extract in diabetic D. melanogaster. Diabetes was induced in flies through a 30% high sucrose diet (HSD), and the effects of different interventions—extract diet (ED), metformin diet (MD), and HSD—on various physiological and biochemical parameters were assessed. Before treatment, the HSD group showed significant increases in glucose and body weight, with no difference in locomotor performance. After the intervention, glucose levels decreased significantly in both ED(P
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- Landmark University, Omu-Aran, Kwara State 1
- Lead City University, Ibadan, Oyo State 1
- Lens Polytechnic, offa, Kwara State. 214
- Madonna University, Elele, Rivers State 20
- Madonna University, Okija, Anambra State 2
- Mcpherson University, Seriki Sotayo, Ogun State 1
- Michael and Cecilia Ibru University, Owhrode, Delta State 1
- Michael Okpara University of Agriculture, Umudike 43
- Michael Otedola Col of Primary Educ. Epe, Lagos (affl To University of Ibadan) 8
- Modibbo Adama University, Yola, Adamawa State 15