Comparative Assessment of the Mitigating Effect of Edta and Selected Plant Exracts on Lead Toxicity of the Renal System
Student: Sandra Nwokoro (Project, 2025)
Department of Biotechnology
Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State
Abstract
ABSTRACT
Lead is a heavy metal found naturally and released by human activities, poses grave health risks, especially for children. It can harm multiple organs, including the kidneys. This study investigates the renal effects of lead and compares the potentials of selected plant extracts and EDTA to mitigate them using 42 albino rats. The normal control (A) group received feed and water only, while lead control (B) group received 50 mg/kg of lead. The treatment groups received lead and 15mg/kg of EDTA (group C), 300mg/g of ginger and garlic (spice) (Group D), turmeric (E), watermelon (F) and citrus (group G) respectively. The study administered treatments orally for 42 days after which the animals were fasted overnight (8 h) and sacrificed and collected blood into Heparin bottles for analysis. Results showed significant(P
Keywords
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Institutions
- Novena University, Ogume, Delta State 1
- Nuhu Bamalli Polytechnic, Zaria, Kaduna State 7
- Nwafor Orizu College of Education, Nsugbe, Anambra State 1
- Obafemi Awolowo University, Ile-Ife, Osun State 15
- Oduduwa University, Ipetumodu, Osun State 9
- Ogun State College of Health Technology, Ilese-Ijebu, Ogun State 1
- Ogun State Institute of Tech(formerly Gateway Ict Poly), Igbesa, Ogun State 4
- Olabisi Onabanjo University, Ago-Iwoye, Ogun State 38
- Ondo State University of Medical Sciences, Laje Road, Ondo, Ondo State 1
- Osun State College of Education, Ila-Orangun 1