Comparative Assessment of the Mitigating Effect of Edta and Selected Plant Exracts on Lead Toxicity of the Renal System
Student: Sandra Nwokoro (Project, 2025)
Department of Biotechnology
Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State
Abstract
ABSTRACT
Lead is a heavy metal found naturally and released by human activities, poses grave health risks, especially for children. It can harm multiple organs, including the kidneys. This study investigates the renal effects of lead and compares the potentials of selected plant extracts and EDTA to mitigate them using 42 albino rats. The normal control (A) group received feed and water only, while lead control (B) group received 50 mg/kg of lead. The treatment groups received lead and 15mg/kg of EDTA (group C), 300mg/g of ginger and garlic (spice) (Group D), turmeric (E), watermelon (F) and citrus (group G) respectively. The study administered treatments orally for 42 days after which the animals were fasted overnight (8 h) and sacrificed and collected blood into Heparin bottles for analysis. Results showed significant(P
Keywords
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Institutions
- Federal College of Education (Tech), Gusau, (Affl To Abu Zaria), Zamfara State 1
- Federal College of Education, Abeokuta (Aff To University of Ibadan), Ogun State 2
- Federal College of Education, Eha-Amufu, Enugu State 1
- Federal College of Education, Kano (Affl To Ahmadu Bello University, Zaria) 1
- Federal College of Education, Kontagora, (Affl To Abu, Zaria), Niger State 2
- Federal College of Education, Okene, (Affl. To University of Ibadan), Kogi State 3
- Federal College of Education, Pankshin, (Affl To Uni of Jos), Plateau State 2
- Federal College of Education, Zaria, Kaduna State (affl To Abu, Zaria) 1
- Federal College of Wildlife Management, New Bussa, Niger State 1
- Federal Cooperative College, Ibadan P.m.b. 5033, Eleyele, Ibadan, Oyo State 3