Anxiolytic Activities of the Methanol Fraction of the Root Bark of Psorospermum Febrifugum (spach)
Student: Chinwoke Sylvia Igboanugo (Project, 2025)
Department of Science Laboratory Technology
University of Nigeria, Nsukka, Enugu State
Abstract
This research evaluated the anxiolytic-like activity of the methanol fraction of the root bark of Psorospermum febrifugum using validated behavioural models of anxiety in rodents. Sixty albino Wistar mice of both sexes were divided into control and treated groups. Behavioural assays included the Open-Field Test, Elevated Plus-Maze, and Light/Dark Box Test. Mice treated with the methanol fraction exhibited dose-dependent increases in exploratory behaviour and time spent in open arms and illuminated compartments, indicative of reduced anxiety. These findings demonstrate that Psorospermum febrifugum possesses significant anxiolytic-like effects and could offer potential therapeutic benefit for anxiety disorders.
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- Mohammed Lawan College of Agriculture, Maiduguri, Borno State 12
- Moshood Abiola Polytechnic, Abeokuta, Ogun State 7
- Nasarawa State University, Keffi, Nasarawa State 8
- Niger Delta University, Wilberforce Island, Bayelsa State 28
- Niger State College of Education, Minna, (Affl To Usmanu Danfodiyo Uni, Sokoto) 1
- Nigeria Maritime University, Okerenkoko, Delta State 1
- Nigerian Army University, Biu, Borno State 3
- Nile University of Nigeria, Abuja 3
- Nnamdi Azikiwe University, Awka, Anambra State 98
- Northwest University, Kano, Kano State 179