Anxiolytic Activities of the Methanol Fraction of the Root Bark of Psorospermum Febrifugum (spach)
Student: Chinwoke Sylvia Igboanugo (Project, 2025)
Department of Science Laboratory Technology
University of Nigeria, Nsukka, Enugu State
Abstract
This research evaluated the anxiolytic-like activity of the methanol fraction of the root bark of Psorospermum febrifugum using validated behavioural models of anxiety in rodents. Sixty albino Wistar mice of both sexes were divided into control and treated groups. Behavioural assays included the Open-Field Test, Elevated Plus-Maze, and Light/Dark Box Test. Mice treated with the methanol fraction exhibited dose-dependent increases in exploratory behaviour and time spent in open arms and illuminated compartments, indicative of reduced anxiety. These findings demonstrate that Psorospermum febrifugum possesses significant anxiolytic-like effects and could offer potential therapeutic benefit for anxiety disorders.
Keywords
For the full publication, please contact the author directly at: igboanugosylvia4@gmail.com
Filters
Institutions
- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 116
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14