Anxiolytic Activities of the Methanol Fraction of the Root Bark of Psorospermum Febrifugum (spach)
Student: Chinwoke Sylvia Igboanugo (Project, 2025)
Department of Science Laboratory Technology
University of Nigeria, Nsukka, Enugu State
Abstract
This research evaluated the anxiolytic-like activity of the methanol fraction of the root bark of Psorospermum febrifugum using validated behavioural models of anxiety in rodents. Sixty albino Wistar mice of both sexes were divided into control and treated groups. Behavioural assays included the Open-Field Test, Elevated Plus-Maze, and Light/Dark Box Test. Mice treated with the methanol fraction exhibited dose-dependent increases in exploratory behaviour and time spent in open arms and illuminated compartments, indicative of reduced anxiety. These findings demonstrate that Psorospermum febrifugum possesses significant anxiolytic-like effects and could offer potential therapeutic benefit for anxiety disorders.
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For the full publication, please contact the author directly at: igboanugosylvia4@gmail.com
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- University of Ilorin, Kwara State 398
- University of Jos, Jos, Plateau State 19
- University of Lagos 18
- University of Maiduguri ( - Elearning), Maiduguri, Borno State 3
- University of Maiduguri, Borno State 109
- University of Nigeria, Nsukka, Enugu State 269
- University of Port Harcourt Teaching Hospital, Port Harcourt , River State 5
- University of Port-Harcourt, Rivers State 174
- University of Uyo, Akwa Ibom State 206
- Usmanu Danfodio University, Sokoto, Sokoto State 245