Anxiolytic Activities of the Methanol Fraction of the Root Bark of Psorospermum Febrifugum (spach)
Student: Chinwoke Sylvia Igboanugo (Project, 2025)
Department of Science Laboratory Technology
University of Nigeria, Nsukka, Enugu State
Abstract
This research evaluated the anxiolytic-like activity of the methanol fraction of the root bark of Psorospermum febrifugum using validated behavioural models of anxiety in rodents. Sixty albino Wistar mice of both sexes were divided into control and treated groups. Behavioural assays included the Open-Field Test, Elevated Plus-Maze, and Light/Dark Box Test. Mice treated with the methanol fraction exhibited dose-dependent increases in exploratory behaviour and time spent in open arms and illuminated compartments, indicative of reduced anxiety. These findings demonstrate that Psorospermum febrifugum possesses significant anxiolytic-like effects and could offer potential therapeutic benefit for anxiety disorders.
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For the full publication, please contact the author directly at: igboanugosylvia4@gmail.com
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Institutions
- Covenant Polytechnic, Aba, Abia State 1
- Covenant University, Canaan Land, Ota, Ogun State 4
- Crawford University of Apostolic Faith Mission Faith City, Igbesa, Ogun State 2
- Crescent University, Abeokuta, Ogun State 1
- Cross Rivers University of Technology, Calabar, Cross Rivers State 142
- Delta State Polytechnic, Ogwashi-Uku, Delta State 11
- Delta State Polytechnic, Otefe, Delta State 12
- Delta State University, Abraka, Delta State 138
- Ebonyi State University, Abakaliki, Ebonyi State 17
- Edo University, Iyamho, Edo State 10