Effect of Zanthoxylum Zanthoxyloides on Gardos Channel, Erythropoietin, and Arginine Vasopressin Ii Receptor in Normal (non-Induced) Wistar Rats
Student: Sunday Adedayo Abusewa (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
This study evaluated the baseline effects of Zanthoxylum zanthoxyloides (Fagara) — a medicinal plant with known pharmacological activities — on Gardos Channel, Erythropoietin (EPO), and Arginine Vasopressin II Receptor (AVPR2) in normal (non-induced) Wistar rats.
Twenty-four male rats were grouped into six sets, receiving either distilled water, Ciklavit, folic acid, or Fagara extract (30 mg/kg and 100 mg/kg).
Results:
Gene expression analysis showed that folic acid treatment produced the highest expression of EPO and AVPR2, while Ciklavit and Fagara also improved gene expression compared to the negative (sodium metabisulphite-induced) control.
Conclusion:
Fagara zanthoxyloides demonstrated promising effects on kidney and red blood cell functions, suggesting potential therapeutic benefits for conditions such as sickle cell disease.
Keywords
For the full publication, please contact the author directly at: sundayabusewa4@gmail.com
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Institutions
- Federal University of Technology, Minna, Niger State 47
- Federal University of Technology, Owerri, Imo State 98
- Federal University Oye-Ekiti, Ekiti State 47
- Federal University, Birnin-Kebbi, Kebbi State 42
- Federal University, Dutse, Jigawa State 8
- Federal University, Dutsin-Ma, Katsina State 64
- Federal University, Gashua, Yobe State 3
- Federal University, Gusau, Zamfara State 14
- Federal University, Kashere, Gombe State 1
- Federal University, Lafia, Nasarawa State 6