Effect of Zanthoxylum Zanthoxyloides on Gardos Channel, Erythropoietin, and Arginine Vasopressin Ii Receptor in Normal (non-Induced) Wistar Rats
Student: Sunday Adedayo Abusewa (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
This study evaluated the baseline effects of Zanthoxylum zanthoxyloides (Fagara) — a medicinal plant with known pharmacological activities — on Gardos Channel, Erythropoietin (EPO), and Arginine Vasopressin II Receptor (AVPR2) in normal (non-induced) Wistar rats.
Twenty-four male rats were grouped into six sets, receiving either distilled water, Ciklavit, folic acid, or Fagara extract (30 mg/kg and 100 mg/kg).
Results:
Gene expression analysis showed that folic acid treatment produced the highest expression of EPO and AVPR2, while Ciklavit and Fagara also improved gene expression compared to the negative (sodium metabisulphite-induced) control.
Conclusion:
Fagara zanthoxyloides demonstrated promising effects on kidney and red blood cell functions, suggesting potential therapeutic benefits for conditions such as sickle cell disease.
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For the full publication, please contact the author directly at: sundayabusewa4@gmail.com
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Institutions
- Ekiti State University 61
- Ekiti State University, Ado-Ekiti, Ekiti State 905
- Elizade University, Ilara-Mokin, Ondo State 100
- Emmanuel Alayande College of Education, Oyo. (affl To Ekiti State Univ) 2
- Enugu State Polytechnic, Iwollo, Enugu State 4
- Enugu State University of Science and Technology, Enugu, Enugu State 32
- Evangel University, Akaeze, Ebonyi State 2
- FCT COLLEGE OF EDUCATION, ZUBA ,( AFFILIATED TO ABU, ZARIA), FCT-ABUJA 5
- Federal College of Agricultural Produce Tech, Hotoro Gra Ext, Kano, Kano State 2
- Federal College of Educ. (Special), Oyo, Oyo State (Aff To Uni. Ibadan) 12