Effect of Zanthoxylum Zanthoxyloides on Gardos Channel, Erythropoietin, and Arginine Vasopressin Ii Receptor in Normal (non-Induced) Wistar Rats
Student: Sunday Adedayo Abusewa (Project, 2025)
Department of Physiology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
This study evaluated the baseline effects of Zanthoxylum zanthoxyloides (Fagara) — a medicinal plant with known pharmacological activities — on Gardos Channel, Erythropoietin (EPO), and Arginine Vasopressin II Receptor (AVPR2) in normal (non-induced) Wistar rats.
Twenty-four male rats were grouped into six sets, receiving either distilled water, Ciklavit, folic acid, or Fagara extract (30 mg/kg and 100 mg/kg).
Results:
Gene expression analysis showed that folic acid treatment produced the highest expression of EPO and AVPR2, while Ciklavit and Fagara also improved gene expression compared to the negative (sodium metabisulphite-induced) control.
Conclusion:
Fagara zanthoxyloides demonstrated promising effects on kidney and red blood cell functions, suggesting potential therapeutic benefits for conditions such as sickle cell disease.
Keywords
For the full publication, please contact the author directly at: sundayabusewa4@gmail.com
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- Samaru College of Agriculture (division of Agric Col, Abu) Zaria, Kaduna State 1
- School of Health Information Mgt (Uch, Ibadan), Oyo State 5
- School of Health Information Mgt, Oau Teaching Hospital, Ile-Ife, Osun State 30
- Skyline University Nigeria, Kano, Kano State 2
- Sokoto State University, Sokoto, Sokoto State 43
- St. Albert The Great Major Seminary, Abeokuta. (affl. To University of Benin) 1
- Sule Lamido University, Kafin Hausa, Jigawa State 4
- Tai Solarin University of Education, Ijagun, Ogun State 19
- Tansian University, Oba, Anambra State 1
- Taraba State University, Jalingo, Taraba State 32