Investigating the Potential of Bridelia Ferruginea Phytochemicals as Plasmodium Falciparum Lactate Dehydrogenase (pfldh) Inhibitors Insilico and Its Effect on the Life Span of Drosophila Melanogaster
Student: Temiloluwa Mofoluwaso Komolafe (Project, 2025)
Department of Science Laboratory Technology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
ABSTRACTMalaria remains a significant public health burden, and the emergence of drug resistant Plasmodium falciparum strains necessitates the discovery of novel inhibitors. This study aimed to investigate the potential of Bridelia ferruginea phytochemicals as inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH) in silico and evaluate their survival effects on Drosophila melanogaster. Bridelia ferruginea, a plant commonly used in traditional medicine, has been reported to possess antimalarial properties. A library of phytochemicals isolated from Bridelia ferruginea was screened for their ability to inhibit PfLDH
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Institutions
- Federal University of Technology, Minna, Niger State 47
- Federal University of Technology, Owerri, Imo State 95
- Federal University Oye-Ekiti, Ekiti State 41
- Federal University, Birnin-Kebbi, Kebbi State 37
- Federal University, Dutse, Jigawa State 6
- Federal University, Dutsin-Ma, Katsina State 63
- Federal University, Gashua, Yobe State 3
- Federal University, Gusau, Zamfara State 14
- Federal University, Kashere, Gombe State 1
- Federal University, Lafia, Nasarawa State 6