Investigating the Potential of Bridelia Ferruginea Phytochemicals as Plasmodium Falciparum Lactate Dehydrogenase (pfldh) Inhibitors Insilico and Its Effect on the Life Span of Drosophila Melanogaster
Student: Temiloluwa Mofoluwaso Komolafe (Project, 2025)
Department of Science Laboratory Technology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
ABSTRACTMalaria remains a significant public health burden, and the emergence of drug resistant Plasmodium falciparum strains necessitates the discovery of novel inhibitors. This study aimed to investigate the potential of Bridelia ferruginea phytochemicals as inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH) in silico and evaluate their survival effects on Drosophila melanogaster. Bridelia ferruginea, a plant commonly used in traditional medicine, has been reported to possess antimalarial properties. A library of phytochemicals isolated from Bridelia ferruginea was screened for their ability to inhibit PfLDH
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Institutions
- Sokoto State University, Sokoto, Sokoto State 42
- St. Albert The Great Major Seminary, Abeokuta. (affl. To University of Benin) 1
- Sule Lamido University, Kafin Hausa, Jigawa State 4
- Tai Solarin University of Education, Ijagun, Ogun State 18
- Tansian University, Oba, Anambra State 1
- Taraba State University, Jalingo, Taraba State 32
- Temple-Gate Polytechnic, Osisioma, Abia State 1
- The Oke-Ogun Polytechnic, Saki, Oyo State 6
- The Polytechnic, Ibadan, Oyo State 13
- THOMAS ADEWUMI UNIVERSITY, OKO-IRESE, KWARA STATE 1