Investigating the Potential of Bridelia Ferruginea Phytochemicals as Plasmodium Falciparum Lactate Dehydrogenase (pfldh) Inhibitors Insilico and Its Effect on the Life Span of Drosophila Melanogaster
Student: Temiloluwa Mofoluwaso Komolafe (Project, 2025)
Department of Science Laboratory Technology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
ABSTRACTMalaria remains a significant public health burden, and the emergence of drug resistant Plasmodium falciparum strains necessitates the discovery of novel inhibitors. This study aimed to investigate the potential of Bridelia ferruginea phytochemicals as inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH) in silico and evaluate their survival effects on Drosophila melanogaster. Bridelia ferruginea, a plant commonly used in traditional medicine, has been reported to possess antimalarial properties. A library of phytochemicals isolated from Bridelia ferruginea was screened for their ability to inhibit PfLDH
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- Mohammed Lawan College of Agriculture, Maiduguri, Borno State 12
- Moshood Abiola Polytechnic, Abeokuta, Ogun State 7
- Nasarawa State University, Keffi, Nasarawa State 8
- Niger Delta University, Wilberforce Island, Bayelsa State 28
- Niger State College of Education, Minna, (Affl To Usmanu Danfodiyo Uni, Sokoto) 1
- Nigeria Maritime University, Okerenkoko, Delta State 1
- Nigerian Army University, Biu, Borno State 3
- Nile University of Nigeria, Abuja 3
- Nnamdi Azikiwe University, Awka, Anambra State 98
- Northwest University, Kano, Kano State 179