Investigating the Potential of Bridelia Ferruginea Phytochemicals as Plasmodium Falciparum Lactate Dehydrogenase (pfldh) Inhibitors Insilico and Its Effect on the Life Span of Drosophila Melanogaster
Student: Temiloluwa Mofoluwaso Komolafe (Project, 2025)
Department of Science Laboratory Technology
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
ABSTRACTMalaria remains a significant public health burden, and the emergence of drug resistant Plasmodium falciparum strains necessitates the discovery of novel inhibitors. This study aimed to investigate the potential of Bridelia ferruginea phytochemicals as inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH) in silico and evaluate their survival effects on Drosophila melanogaster. Bridelia ferruginea, a plant commonly used in traditional medicine, has been reported to possess antimalarial properties. A library of phytochemicals isolated from Bridelia ferruginea was screened for their ability to inhibit PfLDH
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Institutions
- Osun State College of Education, Ila-Orangun(Aff To Ekiti State Uni), Osun State 1
- Osun State College of Education, Ilesa, Osun State. (affl To Univ of Ibadan) 2
- Osun State Polytechnic, Iree, Osun State 467
- Osun State University, Osogbo, Osun State 11
- Our Saviour Institute of Science and Technology (polytechnic) Enugu, Enugu State 1
- PAN-ATLANTIC UNIVERSITY, KM 52 LEKKI-EPE EXPRESSWAY, IBEJU-LEKKI, LAGOS STATE. 14
- Paul University, Awka, Anambra State 2
- Petroleum Training Institute, Effurun, Delta State 1
- Precious Cornerstone University, Ibadan, Oyo State 1
- Prince Abubakar Audu University, Anyigba 30