Effect of Aqueous Extarct of Phyllantus Amarus on Paracetamol Induced Liver Damage of Wister Albino Rats
Student: Eruchiokike Henry-Ihunda (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
The effect of aqueous extract of Phyllantus amarus on paracetamol induced liver damage in wister albino rats in-vitro was investigated. The liver function markers; Alanine transaminase (ALP), Aspartate transaminase (ALT), Alakaline phosphate (ALP), Albumin, Total protein, Total bilirubin and Glucose were measured and the results show that after the adminstration of paracetamol, the concentration of ALP, ALT, AST, Albumin, Total Protein, Total Bilirubin, Glucose in the serum increased as a result of the damaged liver but on administration of varying concentration of the extract over a period of seven days, there was a significant reduction in the concentrations. The result proves that the leaves of Phyllantus amarus have hepatoprotective effect on paracetamol induced liver damage
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Institutions
- HASSAN USMAN KATSINA POLYTECHNIC (NCE), KATSINA, KATSINA STATE 4
- Hassan Usman Katsina Polytechnic, Katsina, Katsina State 5
- Heritage Polytechnic, Ikot Udota, Akwa Ibom State 46
- Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State 8
- Ibrahim Badamasi Babangida University, Lapai, Niger State 24
- Igbinedion University, Okada, Benin City, Edo State 2
- Ignatius Ajuru University of Education, Port Harcourt, Rivers State 8
- Imo State Polytechnic, Umuagwo, Owerri, Imo State 3
- Imo State University, Owerri, Imo State 45
- Institute of Management and Technology, Enugu, Enugu State 11