Effect of Aqueous Extarct of Phyllantus Amarus on Paracetamol Induced Liver Damage of Wister Albino Rats
Student: Eruchiokike Henry-Ihunda (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
The effect of aqueous extract of Phyllantus amarus on paracetamol induced liver damage in wister albino rats in-vitro was investigated. The liver function markers; Alanine transaminase (ALP), Aspartate transaminase (ALT), Alakaline phosphate (ALP), Albumin, Total protein, Total bilirubin and Glucose were measured and the results show that after the adminstration of paracetamol, the concentration of ALP, ALT, AST, Albumin, Total Protein, Total Bilirubin, Glucose in the serum increased as a result of the damaged liver but on administration of varying concentration of the extract over a period of seven days, there was a significant reduction in the concentrations. The result proves that the leaves of Phyllantus amarus have hepatoprotective effect on paracetamol induced liver damage
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- UMA UKPAI SCHOOL OF THEOLOGY, UYO, AKWA IBOM STATE (AFFL TO UNIVERSITY OF UYO) 1
- Umaru Ali Shinkafi Polytechnic, Sokoto, Sokoto State 24
- Umaru Musa Yaradua University, Katsina, Katsina State 28
- Umca, Ilorin (Affiliated To University of Ibadan), Kwara State 1
- University of Abuja, Abuja, Fct 117
- University of Africa, Toru-Orua, Bayelsa State 4
- University of Benin, Benin City, Edo State 362
- University of Calabar Teaching Hospital School of Health Information Mgt. 1
- University of Calabar, Calabar, Cross River State 240
- University of Ibadan, Ibadan, Oyo State 14