Effect of Aqueous Extarct of Phyllantus Amarus on Paracetamol Induced Liver Damage of Wister Albino Rats
Student: Eruchiokike Henry-Ihunda (Project, 2025)
Department of Biochemistry
University of Port-Harcourt, Rivers State
Abstract
The effect of aqueous extract of Phyllantus amarus on paracetamol induced liver damage in wister albino rats in-vitro was investigated. The liver function markers; Alanine transaminase (ALP), Aspartate transaminase (ALT), Alakaline phosphate (ALP), Albumin, Total protein, Total bilirubin and Glucose were measured and the results show that after the adminstration of paracetamol, the concentration of ALP, ALT, AST, Albumin, Total Protein, Total Bilirubin, Glucose in the serum increased as a result of the damaged liver but on administration of varying concentration of the extract over a period of seven days, there was a significant reduction in the concentrations. The result proves that the leaves of Phyllantus amarus have hepatoprotective effect on paracetamol induced liver damage
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Institutions
- Landmark University, Omu-Aran, Kwara State 1
- Lead City University, Ibadan, Oyo State 1
- Lens Polytechnic, offa, Kwara State. 215
- Madonna University, Elele, Rivers State 20
- Madonna University, Okija, Anambra State 2
- Mcpherson University, Seriki Sotayo, Ogun State 1
- Michael and Cecilia Ibru University, Owhrode, Delta State 1
- Michael Okpara University of Agriculture, Umudike 43
- Michael Otedola Col of Primary Educ. Epe, Lagos (affl To University of Ibadan) 8
- Modibbo Adama University, Yola, Adamawa State 15