Behavioural Studies of Hippocampus in Male Wistar Rat Exposed to Doxylamine
Student: David Adedapo Olaosebikan (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Doxylamine is a first-generation antihistamine that primarily functions by antagonizing histamine receptors (H1 receptors) in the central nervous system (CNS), producing sedative and calming effects. As with other sedative antihistamines, doxylamine is known to cross the blood-brain barrier, leading to central nervous system depression. The hippocampus plays a central role in spatial memory, emotional regulation, and learning, all of which are thought to be disrupted under the influence of sedative drugs such as Doxylamine which acts as a histamine antagonist. This study investigates the behavioural effect of prolonged use of doxylamine on the hippocampus.
Keywords
For the full publication, please contact the author directly at: olaosebikandavidadedapo@gmail.com
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Institutions
- Abdul-Gusau Polytechnic, Talata-Mafara, Zamfara State 3
- Abia State Polytechnic, Aba, Abia State 24
- Abia State University, Uturu, Abia State 71
- Abraham Adesanya Polytechnic, Ijebu-Igbo, Ogun State 3
- Abubakar Tafawa Balewa University, Bauchi, Bauchi State 15
- Abubakar Tatari Ali Polytechnic, Bauchi State. (affiliated To Atbu Bauchi) 1
- Achievers University, Owo, Ondo State 6
- Adamawa State University, Mubi, Adamawa State 8
- Adekunle Ajasin University, Akungba-Akoko, Ondo State 26
- Adeleke University, Ede, Osun State 1