Behavioural Studies of Hippocampus in Male Wistar Rat Exposed to Doxylamine
Student: David Adedapo Olaosebikan (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Doxylamine is a first-generation antihistamine that primarily functions by antagonizing histamine receptors (H1 receptors) in the central nervous system (CNS), producing sedative and calming effects. As with other sedative antihistamines, doxylamine is known to cross the blood-brain barrier, leading to central nervous system depression. The hippocampus plays a central role in spatial memory, emotional regulation, and learning, all of which are thought to be disrupted under the influence of sedative drugs such as Doxylamine which acts as a histamine antagonist. This study investigates the behavioural effect of prolonged use of doxylamine on the hippocampus.
Keywords
For the full publication, please contact the author directly at: olaosebikandavidadedapo@gmail.com
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Institutions
- Federal University of Technology, Minna, Niger State 47
- Federal University of Technology, Owerri, Imo State 95
- Federal University Oye-Ekiti, Ekiti State 41
- Federal University, Birnin-Kebbi, Kebbi State 37
- Federal University, Dutse, Jigawa State 6
- Federal University, Dutsin-Ma, Katsina State 63
- Federal University, Gashua, Yobe State 3
- Federal University, Gusau, Zamfara State 14
- Federal University, Kashere, Gombe State 1
- Federal University, Lafia, Nasarawa State 6