Behavioural Studies of Hippocampus in Male Wistar Rat Exposed to Doxylamine
Student: David Adedapo Olaosebikan (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Doxylamine is a first-generation antihistamine that primarily functions by antagonizing histamine receptors (H1 receptors) in the central nervous system (CNS), producing sedative and calming effects. As with other sedative antihistamines, doxylamine is known to cross the blood-brain barrier, leading to central nervous system depression. The hippocampus plays a central role in spatial memory, emotional regulation, and learning, all of which are thought to be disrupted under the influence of sedative drugs such as Doxylamine which acts as a histamine antagonist. This study investigates the behavioural effect of prolonged use of doxylamine on the hippocampus.
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For the full publication, please contact the author directly at: olaosebikandavidadedapo@gmail.com
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Institutions
- AVE-MARIA UNIVERSITY, PIYANKO, NASARAWA STATE 1
- Babcock University, Ilishan-Remo, Ogun State 7
- Bamidele Olumilua University of Edu. Science and Tech. Ikere Ekiti, Ekiti State 454
- Bauchi State College of Agriculture, Bauchi, Bauchi State 1
- Bauchi State University, Gadau, Bauchi State 16
- Bayelsa State Polytechnic, Aleibiri, Bayelsa State 13
- Bayero University, Kano, Kano State 586
- Benue State Polytechnic, Ugbokolo, Benue State 10
- Benue State University, Makurdi, Benue State 47
- Bingham University, Karu, Nasarawa State 3