Behavioural Studies of Hippocampus in Male Wistar Rat Exposed to Doxylamine
Student: David Adedapo Olaosebikan (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Doxylamine is a first-generation antihistamine that primarily functions by antagonizing histamine receptors (H1 receptors) in the central nervous system (CNS), producing sedative and calming effects. As with other sedative antihistamines, doxylamine is known to cross the blood-brain barrier, leading to central nervous system depression. The hippocampus plays a central role in spatial memory, emotional regulation, and learning, all of which are thought to be disrupted under the influence of sedative drugs such as Doxylamine which acts as a histamine antagonist. This study investigates the behavioural effect of prolonged use of doxylamine on the hippocampus.
Keywords
For the full publication, please contact the author directly at: olaosebikandavidadedapo@gmail.com
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Institutions
- Kebbi State University of Science and Technology, Aliero, Kebbi State 6
- Kenule Benson Saro-Wiwa Polytechnic, Bori, Rivers State 18
- Kogi State Polytechnic, Lokoja, Kogi State 4
- Kogi State University, Anyigba 2
- Kwara State College of Health Technology, offa, Kwara State 9
- Kwara State Polytechnic, Ilorin, Kwara State 20
- Kwara State University, Malete, Ilorin, Kwara State 13
- Ladoke Akintola University of Technology, Ogbomoso, Oyo State 39
- Lagos State Poly, Ikorodu, Lagos State 2
- Lagos State University, Ojo, Lagos State 7