Behavioural Studies of Hippocampus in Male Wistar Rat Exposed to Doxylamine
Student: David Adedapo Olaosebikan (Project, 2025)
Department of Anatomy
Ekiti State University, Ado-Ekiti, Ekiti State
Abstract
Doxylamine is a first-generation antihistamine that primarily functions by antagonizing histamine receptors (H1 receptors) in the central nervous system (CNS), producing sedative and calming effects. As with other sedative antihistamines, doxylamine is known to cross the blood-brain barrier, leading to central nervous system depression. The hippocampus plays a central role in spatial memory, emotional regulation, and learning, all of which are thought to be disrupted under the influence of sedative drugs such as Doxylamine which acts as a histamine antagonist. This study investigates the behavioural effect of prolonged use of doxylamine on the hippocampus.
Keywords
For the full publication, please contact the author directly at: olaosebikandavidadedapo@gmail.com
Filters
Institutions
- Landmark University, Omu-Aran, Kwara State 1
- Lead City University, Ibadan, Oyo State 1
- Lens Polytechnic, offa, Kwara State. 214
- Madonna University, Elele, Rivers State 20
- Madonna University, Okija, Anambra State 2
- Mcpherson University, Seriki Sotayo, Ogun State 1
- Michael and Cecilia Ibru University, Owhrode, Delta State 1
- Michael Okpara University of Agriculture, Umudike 43
- Michael Otedola Col of Primary Educ. Epe, Lagos (affl To University of Ibadan) 8
- Modibbo Adama University, Yola, Adamawa State 15