Effect of Metformin on Animals Exposed to Acute Paracetamol Induced Toxicity
Student: Favour Ogechukwu Ashiedu (Project, 2025)
Department of Pharmacology
Delta State University, Abraka, Delta State
Abstract
ABSTRACT Background: Metformin is widely used for treating type 2 diabetes and has potential hepatoprotective effects. Paracetamol overdose, however, can lead to acute liver injury. Aim: To evaluate the effect of metformin on liver enzymes levels in animals exposed to acute paracetamol toxicity. Methods: Wistar rats were divided into four groups: normal control, paracetamol control, metformin-treated, and silymarin-treated. After inducing liver toxicity with paracetamol, liver enzyme levels (ALT, ALP, AST) were measured. Then blood samples were taken for biochemical analysis. Results: Paracetamol significantly increased liver enzyme levels, indicating liver injury. Metformin treatment significantly decreased ALT, ALP, and AST levels compared to the paracetamol control group, showing a protective effect. Conclusion: Metformin significantly mitigates liver enzyme elevation caused by paracetamol toxicity, suggesting its potential as a hepatoprotective agent.
Keywords
For the full publication, please contact the author directly at: ashiedu.favour@delsu.edu.ng
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- Abdul-Gusau Polytechnic, Talata-Mafara, Zamfara State 3
- Abia State Polytechnic, Aba, Abia State 24
- Abia State University, Uturu, Abia State 71
- Abraham Adesanya Polytechnic, Ijebu-Igbo, Ogun State 3
- Abubakar Tafawa Balewa University, Bauchi, Bauchi State 16
- Abubakar Tatari Ali Polytechnic, Bauchi State. (affiliated To Atbu Bauchi) 1
- Achievers University, Owo, Ondo State 6
- Adamawa State University, Mubi, Adamawa State 8
- Adekunle Ajasin University, Akungba-Akoko, Ondo State 27
- Adeleke University, Ede, Osun State 1